Cogent

 

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When 2 is better than 1:
Kromasil diC4 (300A) phase

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ACE Method Development Kits:
3 columns for the price of 1

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Events

Analytica 2018 (Munich, Germany)

10-13 April, 2018

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Discover with MicroSolv

State-of-the-Need products at exceptional value

Using a special technology, the ligands are bonded directly to the TYPE-C silica surface with two separate points of attachment for extreme durability even at very low pH (1.0). This combination gives very stable, efficient and unique HPLC columns that have a wider range of compounds to be separated. Since there are virtually no silanols and the silica surface is slightly hydrophobic, these columns can be used with 100% aqueous mobile phases.

Cogent (Type-C silica-based) phases

Phase Functional group Endcapped Particle, um Pore, A Carbon, %
Silica-C - - 2.2 / 4 120 / 100 -
Diamond Hydride proprietary - 2.2 / 4 120 / 100 2
Bidentate C8 C8 No 2.2 / 4 120 / 100 11 - 14
Bidentate C8 300 C8 No 5 300 5.0
Bidentate C18 C18 No 2.2 / 4 120 / 100 18 - 20
Phenyl Hydride Phenyl No 2.2 / 4 120 / 100 9 - 12
UDA Undecanoic acid No 2.2 / 4 120 / 100 14 - 15
UDC-Cholesterol Alkyl-cholesterol No 2.2 / 4 120 / 100 13 - 14

 

Cogent (Thermally Treated Sol-Gel-Type-B silica-based) phases

Phase Functional group Endcapped Particle, um Pore, A Carbon, %
C27 C27 Yes 5 120 17
C30 C30 No 3 / 5 200 18
HPS High-Performance Columns          
HPS-C8 C8 Yes 5 120 11.5
HPS-C18 C18 Yes 5 120 18.5
HPS-CN cyano Yes 5 120 7.5
HPS-NH2 Amino No 5 120 4.1
HPS-Phenyl Phenyl No 5 120 12

 

HILIC columns vs. Cogent Type-C silica-based columns

Cogent Type-C columns in ANP (Aqueous Normal Phase) mode outperform HILIC columns in the following areas:
- retain nonpolar compounds by RP mechanism
- retain polar compounds by NP mechanism
- BOTH RP and NP mechanisms can operate simultaneously
- can separate samples with BOTH polar and nonpolar analytes
- equilibration time for gradient elution is 5 minutes between runs

  Learn more about HILIC vs. Type-C

 

 

 

Downloads

News

Cogent Diamond Hydride column separates Vancomycin using a simple gradient with water, acetonitrile, and formic acid.
Vancomycin - retention of a highly polar antibiotic
Cogent Phenyl Hydride columns: unique selectivity for compounds with aromatic rings with all the TYPE-C silica benefits. These columns can be used in RP, ANP or NP mode and changed back and forth without damage to the columns.
Orthogonal Assay for Fluoxetine

Catalog

Cogent HPLC Columns Catalog

Brochures

A new technology that saves you time and money
Cogent Type-C Silica-Based Bonded Stationary Phases - Quick Start Instructions

Applications

Pharmaceutical Applications
Clinical Applications
Environmental and Food Applications

 

Useful links

Type-C silica-based HPLC Columns
Type-C silica-based HPLC Columns - Applications

Application Notes
Applications by Compound Name

Application Notes
          Cogent Silica-C
          Cogent Diamond Hydride
          Cogent Bidentate C18
          Cogent UDC-Cholesterol