Regis
Regis Technologies, Inc. has a rich history in serving the life science industry.
Regis manufactures a wide range of chiral, RAM (Restricted Access Media) and IAM (Immobilized Artificial Membrane) specialty HPLC columns. There are four different type of chiral phases: covalently bonded Pirkle, Davankov ligand exchange, covalently bonded 18-crown-ether and polysaccharide coated CSPs. The RAM Direct Injection allows for the chromatography of small molecules in the presence of much larger analytes without extensive sample pretreatment. The IAM Drug Discovery HPLC Column is an ideal tool for high throughput prediction of drug membrane permeability.
Use of chiral columns
| Phase | Class | Applications |
| Pirkle phases | ||
| Whelk-01 | π-electron acceptor/ donor | Useful for the separation of underivatized enantiomers in a number of families including amides, epoxides, esters, ureas, carbamates, ethers, aziridines, phosphonates, aldehydes, ketones, carboxylic acids, alcohols, and non-steroidal anti-inflammatory drugs. Because Whelk-01 is covalently bonded to the support, the phase is compatible with all commonly used mobile phases. Other advantages include column durability, excellent efficiency, and ability to invert elution order. |
| Whelk-02 | π-electron acceptor/ donor | Whelk-02 was designed to improve the resistance of the stationary phase to hydrolysis while using strong organic modifiers such as trifluoroacetic acid. In most cases, the enantioselectivity remains the same as that obtained with the Whelk-01. |
| Leucine | π-electron acceptor | Benzodiazepines |
| Phenylglycine | π-electron acceptor | Resolves a wide variety of compounds containing π-basic groups, including: aryl-substituted cyclic sulfoxides, bi-β-naphthol and its analogs, α-indanol and α-tetralol analogs, and aryl-substituted hydantoins. |
| β-Gem 1 | π-electron acceptor | In many cases, this chiral phase considerably outperforms its widely used analog, phenylglycine. It can separate anilide derivatives of chiral carboxylic acids, including nonsteroidal anti-inflammatory agents. |
| α-Burke 2 | π-electron acceptor | This chiral phase has been specifically designed to separate the enantiomers of β-blockers without chemical derivatization. |
| Pirkle 1-J | π-electron acceptor | Useful for the direct separation of underivatized b-blocker enantiomers. It can also be used for the separation of the enantiomers of arylpropionic acid NSAIDs, as well as other drugs. |
| Naphtylleucine | π-electron donor | This phase resolves DNB derivatives of amino acids as the free acid when used in reversed-phase mode. In the classic normal-phase, this CSP can resolve the amides and esters of DNB amines, alcohols and amino acids. |
| DACH-DNB | π-electron acceptor/ donor | Resolves a broad range of racemate classes including amides, alcohols, esters, ketones, acids, sulfoxides, phosphine oxides, selenoxides, phosphonates, thiophosphineoxide, phosphineselenide, phosphine-borane, beta-lactams, organometallics, atropisomers and heterocycles. |
| ULMO | π-electron acceptor/ donor | This CSP has a general ability to separate the enantiomers of many racemate classes and is particularly good at separating the enantiomers of aryl carbinols. |
| Davankov ligand exchange CSP | ||
| DAVANKOV | ligand exchange | This chiral stationary phase is useful for the separation of underivatized amino acid enantiomers. |
| 18 Crown-Ether CSP | ||
| ChiroSil | crown ether | This CSP is an excellent choice for the separation of amino acids and compounds containing primary amines. This phase is highly durable, has universal solvent compatibility, and has the ability to invert elution order. |
| Polysaccharide coated CSPs | ||
| RegisCell | cellulose | wide range |
| RegisPack | amylose | wide range |
| RegisPack CLA-1 | amylose | wide range |
Packed Columns for SFC Separations
The CELERIS family of achiral stationary phases has been
specifically designed for Supercritical Fluid Chromatography (SFC)
separations, delivering high capacity, broad selectivity, excellent peak
shapes, and reproducible performance over long column lifetimes.
CELERIS high performance phases provide rapid separation and recovery of
purified components at a lower price than competitor offerings, enabling use
of larger column sizes to reduce the number of purification cycles required
to achieve purity of the batch.
News
ChiroSil chiral HPLC columns
for the separation of amino acids and compounds containing primary amines
Chirosil brochure
Regis chiral phases
Screening hits on the
Whelk-01, RegisPack and RegisCell CSPs
Screening hits
Catalogs
REGIS Chiral stationary phase (1)
REGIS Chiral stationary phase (2)
REGIS Chromatography catalog version
1.3
REGIS Chromatography catalog version
1.6
Brochures
REGIS Chiral phases
REGIS Chiral application guide (5)
REGIS Chiral application guide (6)
REGIS Celeris SFC columns
brochure
Misc.
Review of stereochemistry - a
chiral tutorial
Baseline resolution of 17
Cannabinoids
REGIS Online Applications Guide
RegisCell and RegisPack applications
ChiroSil applications
IAM Drug
Discovery Phases (drug membrane permeability prediction)
RAM Direct Injection
